當前位置: 首頁 > 肥胖 > 肥胖都是爸爸害的？ 遺傳基因讓你無法對食物說不
2013 年 07 月 19 日 , , , , , ,

本週美國各大媒體都有報導的一件事，就是四年一度的美國童軍大露營，今年開始規定BMI指數超過40的人不得參加，32到39.9之間的必須提出自 己的醫療資訊以供審核。美國童軍組織表示提倡健康的身心是他們的宗旨之一，而且也必須考量參加野外露營活動的安全性。不知道美國胖童軍是否會因此控告童軍 組織歧視，因為最近兩項研究都說明光是父親吃多了就可能生出胖小孩，有肥胖基因的人對高熱量食物的誘惑簡直不堪一擊。

胖童軍不要來

2013年美國童軍大露營(2013 National Scout jamboree) 預估有3萬人參加，工作人員約7000人，訪客也將達5000人，為期10天的野外活動在西維吉尼亞州一處山上舉行，包含許多「高度探險活動」，例如泛 舟、攀岩、抱石(bouldering)、滑板、山地自行車、小輪車(BMX riding)、滑翔、4.8公里爬山遠足與900公尺溜索(zip line)。

2013 jamboree 01
(圖片來源: 2013 National Scout jamboree)

想必這是美國文化中的盛事，因為不但活動規模龐大，從1937年第一次舉辦以來共有七位美國總統曾蒞臨現場，因此今年主辦單位訂出了BMI指標做為參加門 檻，雖然強調這是為了促使大眾更加注意自己的健康，也是為了避免在活動中受傷，但還是引起不少討論，有專家便表示與其禁止他們參加，不如調整項目或標準， 讓超重的人有戶外活動的機會，讓他們得以朝向健康的生活邁進。

2013 jamboree 02
(圖片來源: 2013 National Scout jamboree)

胖童軍：都是老爸害的

BMI 指數40以上其實已經算是很重的，美國童軍組織的考量並非沒有道理，不過他們的決定想必會引很多胖童軍的抗議，而且他們現在有更多理由了。澳洲阿德雷德大 學(University of Adelaide)的一組研究團隊發表報告顯示，肥的公小鼠精子中有「分子證據」說明肥胖或其他代謝疾病可以傳給兒輩與孫輩，但效應遞減。研究報告主筆人 Tod Fullston表示，一個父親的飲食習慣會改變他的精子裡微RNA(microRNA)的組成，從而影響胚胎的形成，造成日後的肥胖或可能的代謝疾病。

Sperm_stained
(圖片來源: Wikimedia Commons)

這項研究刊載於最新一期的「美國實驗生物學聯會期刊」(The FASEB Journal)，指出對女性後代而言有較多變胖的機會，而不論男女，演變成類似第二型糖尿病的代謝疾病的機率也有增加，即使胖的公小鼠並沒有顯現任何糖尿病的徵兆。

Tod Fullston認為，如果在人體內也發生這些小鼠身上的實驗結果，代表我們還有一個尚未開啟的兒童肥胖研究領域；過往對於胎兒的健康，大家總是關心負責懷孕的母親的身體狀況，如今，對於父親的飲食習慣與運動等等方面，也許同樣不能輕忽。

被害的經過

除了每個胖子的父親可能從此脫不了關係外，另一項研究則對FTO這個肥胖基因在人體內的運作過程有了更多瞭解。FTO是2007年幾項研究發現的肥胖危險因子，父母雙方都可能遺傳給下一代，擁有這種基因的人不但吃的比沒有基因的人多，平均體重也多3公斤。

但在那之後，對於FTO基因的運作方式一直沒有找到答案。最新一期的「臨床研究期刊」(Journal of Clinical Investigation)刊載了一份倫敦大學學院(University College London)的研究，驚人地指出，就算你吃飽了，FTO基因讓你更想吃東西，尤其是高熱量食物。因為FTO產生一種促進飲食的激素，讓人即使吃飽了，仍會感到饑餓。

Rachel Batterham的研究團隊找來359位正常體重的歐洲男人，其中有45人是同時從父母遺傳了FTO的高危險群，其他則沒有。研究團隊特別注意排除了一 些其他可能影響實驗的因素，例如教育程度。他們從中各選10人，在一次標準用餐的前後，分別問他們感到饑餓的程度。結果高危險群在餐後，覺得饑餓的程度與 血液中的促食激素都比其他人高。

下視丘也是幫凶

接著研究團隊讓另外24人在用餐前後，分別看一些高、低熱量食物或不是食 物的圖片，用功能性磁振造影(fMRI)觀察腦部變化，同時也詢問他們的看法與抽血檢查。結果他們發現即使在用餐後，高危險群看著高熱量的圖片仍然覺得它 很吸引人，他們的腦部反應也與其他人不同，特別是主管飲食功能的下視丘。

這項研究同樣指出FTO會影響轉錄微RNA的過程，使得微RNA影 響了激素的生成。專業減重醫師Jeremy Korman對此評論說，根據這項實驗結果，未來可以研發控制促食激素的藥劑，但事實上還有其他因素要考慮，比方說腸道會釋出另一種「吃飽了，停止進食」 的激素，因此不能只管控制促食激素。他建議至少多吃蛋白質少吃碳水化合物，以降低饑餓的感覺。他們兩人也都同意像「袖狀胃切除術」(sleeve gastrectomy)也是個辦法，因為它減少了生成促食激素的部位。

袖狀胃切除術
▲經過「袖狀胃切除術」後，胃（本圖上半部）變得很小。(圖片來源: NCBI)

結論

  1. 研究證實父親的飲食習慣會透過精子影響兒輩與孫輩，讓後代容易變胖或其他類似第二型糖尿病的代謝疾病。
  2. 研究說明肥胖基因FTO產生的促食激素，讓人一直想吃東西，它也影響腦部，讓人就算吃飽了，看到高熱量食物還是想咬一口。
  3. 看完這篇文章請不要一拳打在令尊的大肚腩上，他也可能跟你一樣是被害人。

(封面圖片來源: 2013 National Scout jamboree)

延伸閱讀

相關資料

 

    回覆 # 1F
    於 2024-04-02 18:58:45 發表

    Nice article inspiring thanks. Hello Administ . Website Giriş için Tıklayın: ganobet
    回覆 # 1F
    於 2024-03-18 16:07:32 發表

    Good info. Lucky me I reach on your website by accident, I bookmarked it.
    回覆 # 1F
    於 2024-03-18 08:41:04 發表

    I really love to read such an excellent article. Helpful article. Hello Administ .
    回覆 # 1F
    於 2024-03-17 04:39:15 發表

    Hello! I could have sworn I’ve been to this blog before but after browsing through some of the post I realized it’s new to me.
    回覆 # 1F
    於 2024-03-17 01:51:51 發表

    Great post thank you. Hello Administ .
    回覆 # 1F
    於 2024-03-16 14:08:18 發表

    Nice article inspiring thanks. Hello Administ .
    回覆 # 1F
    於 2024-03-16 00:03:51 發表

    I really love to read such an excellent article. Helpful article. Hello Administ .
    回覆 # 1F
    於 2024-03-16 00:03:35 發表

    Thank you great posting about essential oil. Hello Administ .
    回覆 # 1F
    於 2024-03-15 17:41:02 發表

    Thank you great posting about essential oil. Hello Administ .
    回覆 # 1F
    於 2024-03-15 14:42:10 發表

    Great post thank you. Hello Administ . Website Giriş için Tıklayın: jojobet
    回覆 # 1F
    於 2024-03-15 10:49:13 發表

    Good info. Lucky me I reach on your website by accident, I bookmarked it.
    回覆 # 1F
    於 2024-03-15 02:52:57 發表
    回覆 # 1F
    於 2024-03-14 18:34:15 發表

    Hi, just required you to know I he added your site to my Google bookmarks due to your layout. But seriously, I believe your internet site has 1 in the freshest theme I??ve came across.
    回覆 # 1F
    於 2024-03-14 18:26:05 發表

    Great post thank you. Hello Administ . Website Giri� i�in T�klay�n: Bahisal Giri�
    回覆 # 1F
    於 2024-03-14 18:25:43 發表

    Thank you for great article. Hello Administ .Website Giri� i�in T�klay�n: Bahisal Giri�
    回覆 # 1F
    於 2024-03-11 23:17:45 發表

    Thank you for great information. Hello Administ .
    回覆 # 1F
    於 2024-03-11 17:02:58 發表

    Thank you for great article. Hello Administ .
    回覆 # 1F
    於 2024-03-11 13:46:12 發表

    Hello! I could have sworn I’ve been to this blog before but after browsing through some of the post I realized it’s new to me.
    回覆 # 1F
    於 2024-03-11 10:27:51 發表

    Thank you for content. Area rugs and online home decor store. Hello Administ .
    回覆 # 1F
    於 2024-03-11 01:57:30 發表

    Thank you great post. Hello Administ .
    回覆 # 1F
    於 2024-03-11 01:38:41 發表

    After all, what a great site and informative posts, I will upload inbound link – bookmark this web site? Regards, Reader.
    回覆 # 1F
    於 2024-03-10 02:55:15 發表

    Thank you great post. Hello Administ .
    回覆 # 1F
    於 2024-03-09 20:01:51 發表

    Nice article inspiring thanks. Hello Administ .
    回覆 # 1F
    於 2024-03-09 19:07:40 發表

    Nice article inspiring thanks. Hello Administ .
    回覆 # 1F
    於 2024-03-09 09:05:06 發表

    After all, what a great site and informative posts, I will upload inbound link – bookmark this web site? Regards, Reader.
    回覆 # 1F
    於 2024-03-06 06:59:49 發表

    Hi, just required you to know I he added your site to my Google bookmarks due to your layout. But seriously, I believe your internet site has 1 in the freshest theme I??ve came across.
    回覆 # 1F
    於 2024-03-04 13:39:16 發表

    Everything is very open and very clear explanation of issues. was truly information. bahiscom bahiscom
    回覆 # 1F
    於 2024-03-03 11:41:03 發表

    Thank you great posting about essential oil. Hello Administ .
    回覆 # 1F
    於 2024-02-29 14:04:31 發表

    Thank you for great content. Hello Administ.
    回覆 # 1F
    於 2024-02-29 14:04:07 發表

    Thank you great posting about essential oil. Hello Administ .
    回覆 # 1F
    於 2024-02-29 12:49:19 發表

    I really love to read such an excellent article. Helpful article. Hello Administ .
    回覆 # 1F
    於 2024-02-29 12:49:03 發表

    Hello! I could have sworn I’ve been to this blog before but after browsing through some of the post I realized it’s new to me.
    回覆 # 1F
    於 2024-02-29 12:40:24 發表

    Thank you for great information. Hello Administ .
    回覆 # 1F
    於 2024-02-29 12:39:31 發表

    Hi, just required you to know I he added your site to my Google bookmarks due to your layout. But seriously, I believe your internet site has 1 in the freshest theme I??ve came across.
    回覆 # 1F
    於 2024-02-29 00:22:33 發表

    Nice article inspiring thanks. Hello Administ .
    回覆 # 1F
    於 2024-02-29 00:14:16 發表

    Everything is very open and very clear explanation of issues. was truly information.
    回覆 # 1F
    於 2024-02-29 00:02:01 發表

    Hi, just required you to know I he added your site to my Google bookmarks due to your layout. But seriously, I believe your internet site has 1 in the freshest theme I??ve came across.
    回覆 # 1F
    於 2024-02-28 23:56:07 發表

    Thank you for great information. Hello Administ .
    回覆 # 1F
    於 2024-02-28 23:15:29 發表

    Thank you great post. Hello Administ .
    回覆 # 1F
    於 2024-02-28 23:12:48 發表

    After all, what a great site and informative posts, I will upload inbound link – bookmark this web site? Regards, Reader.
    回覆 # 1F
    於 2024-02-25 20:19:02 發表

    Thank you for great information. Hello Administ .
    回覆 # 1F
    於 2024-02-25 20:07:25 發表

    Thank you great post. Hello Administ .
    回覆 # 1F
    於 2024-02-25 19:11:03 發表

    I really love to read such an excellent article. Helpful article. Hello Administ .
    回覆 # 1F
    於 2024-02-25 18:59:19 發表

    Everything is very open and very clear explanation of issues. was truly information.
    回覆 # 1F
    於 2024-02-25 18:47:24 發表

    Great post thank you. Hello Administ .
    回覆 # 1F
    於 2024-02-25 18:40:20 發表

    Good info. Lucky me I reach on your website by accident, I bookmarked it.
    回覆 # 1F
    於 2024-02-25 17:44:09 發表

    Everything is very open and very clear explanation of issues. was truly information.
    回覆 # 1F
    於 2024-02-25 17:28:45 發表

    I really love to read such an excellent article. Helpful article. Hello Administ .
    回覆 # 1F
    於 2024-02-25 17:24:27 發表

    Thank you for great article. Hello Administ .
    回覆 # 1F
    於 2024-02-25 15:01:31 發表

    Hi, just required you to know I he added your site to my Google bookmarks due to your layout. But seriously, I believe your internet site has 1 in the freshest theme I??ve came across.
    回覆 # 1F
    於 2024-02-25 14:57:31 發表

    Thank you great post. Hello Administ .
    回覆 # 1F
    於 2024-02-25 14:56:12 發表

    Thank you for great information. Hello Administ .
    回覆 # 1F
    於 2024-02-25 14:20:27 發表

    Hello! I could have sworn I’ve been to this blog before but after browsing through some of the post I realized it’s new to me.
    回覆 # 1F
    於 2024-02-25 14:19:52 發表

    After all, what a great site and informative posts, I will upload inbound link – bookmark this web site? Regards, Reader.
    回覆 # 1F
    於 2024-02-24 00:31:58 發表

    Hi, just required you to know I he added your site to my Google bookmarks due to your layout. But seriously, I believe your internet site has 1 in the freshest theme I??ve came across.
    回覆 # 1F
    於 2024-02-24 00:21:04 發表

    Nice article inspiring thanks. Hello Administ .
    回覆 # 1F
    於 2024-02-23 23:56:41 發表

    Thank you for content. Area rugs and online home decor store. Hello Administ .
    回覆 # 1F
    於 2024-02-23 23:03:55 發表

    Thank you for great article. Hello Administ .
    回覆 # 1F
    於 2024-02-23 21:12:35 發表

    I really love to read such an excellent article. Helpful article. Hello Administ .
    回覆 # 1F
    於 2024-02-23 19:43:14 發表

    Hello! I could have sworn I’ve been to this blog before but after browsing through some of the post I realized it’s new to me.
    回覆 # 1F
    於 2024-02-23 18:55:28 發表

    Thank you for content. Area rugs and online home decor store. Hello Administ .
    回覆 # 1F
    於 2024-02-23 18:48:24 發表

    Hi, just required you to know I he added your site to my Google bookmarks due to your layout. But seriously, I believe your internet site has 1 in the freshest theme I??ve came across.
    回覆 # 1F
    於 2024-02-23 18:12:44 發表

    Thank you great posting about essential oil. Hello Administ .
    回覆 # 1F
    於 2024-02-23 08:50:17 發表

    Thank you for content. Area rugs and online home decor store. Hello Administ .
    回覆 # 1F
    於 2024-02-22 20:55:12 發表

    Great post thank you. Hello Administ .
    回覆 # 1F
    於 2024-02-22 20:36:28 發表

    Thank you great posting about essential oil. Hello Administ .
    回覆 # 1F
    於 2024-02-22 20:35:53 發表

    Thank you for content. Area rugs and online home decor store. Hello Administ .
    回覆 # 1F
    於 2024-02-22 20:32:05 發表

    Thank you great post. Hello Administ .
    回覆 # 1F
    於 2024-02-22 20:15:41 發表

    Thank you great posting about essential oil. Hello Administ .
    回覆 # 1F
    於 2024-02-22 20:10:05 發表

    Nice article inspiring thanks. Hello Administ .
    回覆 # 1F
    於 2024-02-22 20:07:29 發表

    Good info. Lucky me I reach on your website by accident, I bookmarked it.
    回覆 # 1F
    於 2024-02-22 20:00:56 發表

    Thank you great posting about essential oil. Hello Administ .
    回覆 # 1F
    於 2024-02-22 20:00:35 發表

    Thank you for great information. Hello Administ .
    回覆 # 1F
    於 2024-02-22 19:59:42 發表

    Hello! I could have sworn I’ve been to this blog before but after browsing through some of the post I realized it’s new to me.
    回覆 # 1F
    於 2024-02-22 19:31:56 發表

    Nice article inspiring thanks. Hello Administ .
    回覆 # 1F
    於 2024-02-22 19:00:47 發表

    Great post thank you. Hello Administ .
    回覆 # 1F
    於 2024-02-22 17:54:03 發表

    Everything is very open and very clear explanation of issues. was truly information.
    回覆 # 1F
    於 2024-02-22 06:53:57 發表

    Everything is very open and very clear explanation of issues. was truly information.
    回覆 # 1F
    於 2024-02-22 06:42:16 發表

    Hi, just required you to know I he added your site to my Google bookmarks due to your layout. But seriously, I believe your internet site has 1 in the freshest theme I??ve came across.
    回覆 # 1F
    於 2024-02-22 06:37:59 發表

    Great post thank you. Hello Administ .
    回覆 # 1F
    於 2024-02-22 06:30:05 發表

    Nice article inspiring thanks. Hello Administ .
    回覆 # 1F
    於 2024-02-22 06:21:08 發表

    Hello! I could have sworn I’ve been to this blog before but after browsing through some of the post I realized it’s new to me.
    回覆 # 1F
    於 2024-02-22 06:13:55 發表

    Thank you for great article. Hello Administ .
    回覆 # 1F
    於 2024-02-22 06:05:50 發表

    After all, what a great site and informative posts, I will upload inbound link – bookmark this web site? Regards, Reader.
    回覆 # 1F
    於 2024-02-22 06:04:58 發表

    I really love to read such an excellent article. Helpful article. Hello Administ .
    回覆 # 1F
    於 2024-02-22 06:02:56 發表

    Good info. Lucky me I reach on your website by accident, I bookmarked it.
    回覆 # 1F
    於 2024-02-22 03:51:21 發表

    Thank you great posting about essential oil. Hello Administ .
    回覆 # 1F
    於 2024-02-21 15:36:49 發表

    Thank you great post. Hello Administ .
    回覆 # 1F
    於 2024-02-21 13:45:42 發表

    Thank you great posting about essential oil. Hello Administ .
    回覆 # 1F
    於 2024-02-21 13:09:32 發表

    Hi, just required you to know I he added your site to my Google bookmarks due to your layout. But seriously, I believe your internet site has 1 in the freshest theme I??ve came across.
    回覆 # 1F
    於 2024-02-20 23:03:09 發表

    Thank you great post. Hello Administ .
    回覆 # 1F
    於 2024-02-20 22:01:23 發表

    Hi, just required you to know I he added your site to my Google bookmarks due to your layout. But seriously, I believe your internet site has 1 in the freshest theme I??ve came across.
    回覆 # 1F
    於 2024-02-20 21:30:56 發表

    I really love to read such an excellent article. Helpful article. Hello Administ .
    回覆 # 1F
    於 2024-02-20 21:20:09 發表

    After all, what a great site and informative posts, I will upload inbound link – bookmark this web site? Regards, Reader.
    回覆 # 1F
    於 2024-02-20 20:51:52 發表

    Thank you for great information. Hello Administ .
    回覆 # 1F
    於 2024-02-20 05:31:01 發表

    Good info. Lucky me I reach on your website by accident, I bookmarked it. asyabahis asyabahis
    回覆 # 1F
    於 2024-02-19 19:56:22 發表

    Thank you great post. Hello Administ .
    回覆 # 1F
    於 2024-02-19 17:49:27 發表

    Thank you great posting about essential oil. Hello Administ .
    回覆 # 1F
    於 2024-02-19 17:46:12 發表

    Thank you great posting about essential oil. Hello Administ .
    回覆 # 1F
    於 2024-02-19 17:34:42 發表

    Good info. Lucky me I reach on your website by accident, I bookmarked it.
    回覆 # 1F
    於 2024-02-19 17:30:22 發表

    Thank you for great content. Hello Administ.
    回覆 # 1F
    於 2024-02-19 17:26:16 發表

    Thank you great post. Hello Administ .
    回覆 # 1F
    於 2024-02-19 17:13:08 發表

    Nice article inspiring thanks. Hello Administ .
    回覆 # 1F
    於 2024-02-19 17:08:38 發表

    Great post thank you. Hello Administ .
    回覆 # 1F
    於 2024-02-19 17:06:19 發表

    Great post thank you. Hello Administ .
    回覆 # 1F
    於 2024-02-19 17:05:51 發表

    Great post thank you. Hello Administ .
    回覆 # 1F
    於 2024-02-19 17:02:02 發表

    Everything is very open and very clear explanation of issues. was truly information.
    回覆 # 1F
    於 2024-02-19 16:59:31 發表

    Good info. Lucky me I reach on your website by accident, I bookmarked it.
    回覆 # 1F
    於 2024-02-19 16:39:09 發表

    Thank you for great information. Hello Administ .
    回覆 # 1F
    於 2024-02-19 13:53:17 發表

    Thank you for great content. Hello Administ.
    回覆 # 1F
    於 2024-02-18 01:21:22 發表

    Hi, just required you to know I he added your site to my Google bookmarks due to your layout. But seriously, I believe your internet site has 1 in the freshest theme I??ve came across.
    回覆 # 1F
    於 2024-02-17 22:12:21 發表

    Good info. Lucky me I reach on your website by accident, I bookmarked it.
    回覆 # 1F
    於 2024-02-17 17:59:08 發表

    I really love to read such an excellent article. Helpful article. Hello Administ .
    回覆 # 1F
    於 2024-02-17 17:07:22 發表

    Great post thank you. Hello Administ .
    回覆 # 1F
    於 2024-02-17 16:30:53 發表

    Hi, just required you to know I he added your site to my Google bookmarks due to your layout. But seriously, I believe your internet site has 1 in the freshest theme I??ve came across.
    回覆 # 1F
    於 2024-02-06 12:34:22 發表

    Thank you for content. Area rugs and online home decor store. Hello Administ . Website Giriş için Tıklayın: asyabahisgo1.com
    回覆 # 1F
    於 2024-02-06 01:50:39 發表

    Thank you for content. Area rugs and online home decor store. Hello Administ . Website Giriş için Tıklayın. Starzbet
    回覆 # 1F
    於 2024-02-06 01:50:16 發表

    Good info. Lucky me I reach on your website by accident, I bookmarked it. Website Giriş için Tıklayın. Starzbet
    回覆 # 1F
    於 2024-02-02 02:56:11 發表

    Everything is very open and very clear explanation of issues. was truly information.Website Giriş için Tıklayın: tipobet
    回覆 # 1F
    於 2024-01-31 21:39:37 發表

    Hi, just required you to know I he added your site to my Google bookmarks due to your layout. But seriously, I believe your internet site has 1 in the freshest theme I??ve came across. Website Giriş için Tıklayın. Starzbet
    回覆 # 1F
    於 2024-01-31 04:04:40 發表

    Nice article inspiring thanks. Hello Administ . Website Giriş için Tıklayın. Starzbet
    回覆 # 1F
    於 2024-01-31 04:04:16 發表

    Thank you for great information. Hello Administ . Website Giriş için Tıklayın. Starzbet
    回覆 # 1F
    於 2024-01-30 13:16:45 發表

    I really love to read such an excellent article. Helpful article. Hello Administ . Website Giriş için Tıklayın: tipobet
    回覆 # 1F
    於 2024-01-29 19:00:57 發表

    Thank you great post. Hello Administ .Website Giriş için Tıklayın. Starzbet
    回覆 # 1F
    於 2024-01-29 19:00:39 發表

    Hello! I could have sworn I’ve been to this blog before but after browsing through some of the post I realized it’s new to me. Website Giriş için Tıklayın. Starzbet
    回覆 # 1F
    於 2024-01-29 18:46:52 發表

    After all, what a great site and informative posts, I will upload inbound link – bookmark this web site? Regards, Reader. Websiteye Giriş için Tıklayın. a href=”https://cutt.ly/SahabetSosyal/” title=”Sahabet” rel=”dofollow”>Sahabet
    回覆 # 1F
    於 2024-01-29 13:56:24 發表

    Hi, just required you to know I he added your site to my Google bookmarks due to your layout. But seriously, I believe your internet site has 1 in the freshest theme I??ve came across.Onwin Giriş için Tıklayın onwin
    回覆 # 1F
    於 2024-01-29 11:54:13 發表

    Good info. Lucky me I reach on your website by accident, I bookmarked it. Onwin Giriş için Tıklayın onwin
    回覆 # 1F
    於 2024-01-29 06:54:04 發表

    I really love to read such an excellent article. Helpful article. Hello Administ . Website Giriş için Tıklayın. Starzbet
    回覆 # 1F
    於 2024-01-29 03:28:54 發表

    Nice article inspiring thanks. Hello Administ . Websiteye Giriş için Tıklayın. a href=”https://cutt.ly/SahabetSosyal/” title=”Sahabet” rel=”dofollow”>Sahabet
    回覆 # 1F
    於 2024-01-29 03:28:37 發表

    Thank you great posting about essential oil. Hello Administ . Websiteye Giriş için Tıklayın. a href=”https://cutt.ly/SahabetSosyal/” title=”Sahabet” rel=”dofollow”>Sahabet
    回覆 # 1F
    於 2024-01-28 18:46:29 發表

    Thank you for great information. Hello Administ . Website Giriş için Tıklayın: tipobet
    回覆 # 1F
    於 2024-01-28 16:50:32 發表

    Thank you for great content. Hello Administ. Website Giriş için Tıklayın: tipobet
    回覆 # 1F
    於 2024-01-26 01:11:54 發表

    Thank you for great content. Hello Administ. Websiteye Giriş için Tıklayın. a href=”https://cutt.ly/SahabetSosyal/” title=”Sahabet” rel=”dofollow”>Sahabet
    回覆 # 1F
    於 2024-01-25 19:10:37 發表

    Hi, just required you to know I he added your site to my Google bookmarks due to your layout. But seriously, I believe your internet site has 1 in the freshest theme I??ve came across.Website Giriş için Tıklayın: tipobet
    回覆 # 1F
    於 2024-01-25 17:13:10 發表

    Good info. Lucky me I reach on your website by accident, I bookmarked it. Website Giriş için Tıklayın: tipobet
    回覆 # 1F
    於 2024-01-25 14:04:56 發表

    Thank you for great article. Hello Administ .Onwin Giriş için Tıklayın onwin
    回覆 # 1F
    於 2024-01-23 19:21:43 發表

    Hello! I could have sworn I’ve been to this blog before but after browsing through some of the post I realized it’s new to me.Website Giriş için Tıklayın: tipobet
    回覆 # 1F
    於 2024-01-16 01:34:56 發表

    Hi, just required you to know I he added your site to my Google bookmarks due to your layout. But seriously, I believe your internet site has 1 in the freshest theme I??ve came across.
    回覆 # 1F
    於 2024-01-15 18:36:49 發表

    Thank you for great article. Hello Administ .
    回覆 # 1F
    於 2024-01-15 05:55:06 發表

    Thank you for great information. Hello Administ .
    回覆 # 1F
    於 2024-01-14 22:34:59 發表

    Thank you great posting about essential oil. Hello Administ . Website : cami halısı
    回覆 # 1F
    於 2024-01-14 22:34:25 發表

    I really love to read such an excellent article. Helpful article. Hello Administ . Website : cami halısı
    回覆 # 1F
    於 2024-01-13 20:19:25 發表

    Great post thank you. Hello Administ .
    回覆 # 1F
    於 2024-01-13 20:18:50 發表

    Thank you for great information. Hello Administ .
    回覆 # 1F
    於 2024-01-13 02:54:38 發表

    Thank you for content. Area rugs and online home decor store. Hello Administ .
    回覆 # 1F
    於 2024-01-12 00:54:03 發表

    Thank you for great information. Hello Administ .
    回覆 # 1F
    於 2024-01-12 00:53:47 發表

    Hi, just required you to know I he added your site to my Google bookmarks due to your layout. But seriously, I believe your internet site has 1 in the freshest theme I??ve came across.
    回覆 # 1F
    於 2024-01-10 14:13:59 發表

    Thank you great post. Hello Administ .
    回覆 # 1F
    於 2024-01-10 06:37:19 發表

    Nice article inspiring thanks. Hello Administ .
    回覆 # 1F
    於 2024-01-01 00:47:41 發表

    Everything is very open and very clear explanation of issues. was truly information.
    回覆 # 1F
    於 2023-12-29 06:13:55 發表

    Thank you for content. Area rugs and online home decor store. Hello Administ . Website : cami halısı
    回覆 # 1F
    於 2023-12-29 06:13:31 發表

    Thank you great posting about essential oil. Hello Administ . Website : cami halısı
    回覆 # 1F
    於 2023-12-28 20:34:00 發表

    Thank you for great content. Hello Administ. Onwin Giriş Website: onwin
    回覆 # 1F
    於 2023-12-26 18:09:45 發表

    Good info. Lucky me I reach on your website by accident, I bookmarked it. Website : https://www.saricahali.com.tr/
    回覆 # 1F
    於 2023-12-26 18:09:24 發表

    Thank you for content. Area rugs and online home decor store. Hello Administ . Website : https://www.saricahali.com.tr/
    回覆 # 1F
    於 2023-12-26 16:44:33 發表

    Everything is very open and very clear explanation of issues. was truly information.
    回覆 # 1F
    於 2023-12-26 04:36:22 發表

    After all, what a great site and informative posts, I will upload inbound link – bookmark this web site? Regards, Reader. Casibom Website Giriş : Casibom
    回覆 # 1F
    於 2023-12-25 23:38:44 發表

    Thank you great post. Hello Administ . Onwin , Onwin Giriş onwin
    回覆 # 1F
    於 2023-12-25 04:44:00 發表

    Thank you for content. Area rugs and online home decor store. Hello Administ .
    回覆 # 1F
    於 2023-12-24 23:20:26 發表

    Nice article inspiring thanks. Hello Administ .
    回覆 # 1F
    於 2023-12-24 21:32:30 發表

    Hi, just required you to know I he added your site to my Google bookmarks due to your layout. But seriously, I believe your internet site has 1 in the freshest theme I??ve came across.
    回覆 # 1F
    於 2023-12-24 10:04:55 發表

    Good info. Lucky me I reach on your website by accident, I bookmarked it.
    回覆 # 1F
    於 2023-12-20 00:51:24 發表

    Great post thank you. Hello Administ . bahis forum bahis forum
    回覆 # 1F
    於 2023-12-19 15:37:09 發表

    Thank you great post. Hello Administ . hdxvipizle hdxvipizle
    回覆 # 1F
    於 2023-12-19 13:06:32 發表

    Thank you for content. Area rugs and online home decor store. Hello Administ . venusbet venusbet
    回覆 # 1F
    於 2023-12-19 10:09:04 發表

    Everything is very open and very clear explanation of issues. was truly information. venusbet deneme bonusu veren siteler
    回覆 # 1F
    於 2023-12-19 02:15:25 發表

    Thank you for content. Area rugs and online home decor store. Hello Administ . sollet sollet
    回覆 # 1F
    於 2023-12-14 14:48:56 發表

    Hello! I could have sworn I’ve been to this blog before but after browsing through some of the post I realized it’s new to me. Website : https://www.saricahali.com.tr/
    回覆 # 1F
    於 2023-12-14 10:31:28 發表

    Thank you great posting about essential oil. Hello Administ . Website : https://www.saricahali.com.tr/
    回覆 # 1F
    於 2023-12-14 09:10:44 發表

    I really love to read such an excellent article. Helpful article. Hello Administ .
    回覆 # 1F
    於 2023-12-14 02:52:05 發表

    Nice article inspiring thanks. Hello Administ .
    回覆 # 1F
    於 2023-12-14 02:51:48 發表

    I really love to read such an excellent article. Helpful article. Hello Administ .
    回覆 # 1F
    於 2023-12-14 02:25:50 發表

    Thank you for great article. Hello Administ .
    回覆 # 1F
    於 2023-12-14 02:25:34 發表

    Hi, just required you to know I he added your site to my Google bookmarks due to your layout. But seriously, I believe your internet site has 1 in the freshest theme I??ve came across.
    回覆 # 1F
    於 2023-12-14 00:48:29 發表

    Hi, just required you to know I he added your site to my Google bookmarks due to your layout. But seriously, I believe your internet site has 1 in the freshest theme I??ve came across.
    回覆 # 1F
    於 2023-12-14 00:44:27 發表

    Nice article inspiring thanks. Hello Administ .
    回覆 # 1F
    於 2023-12-14 00:44:01 發表

    After all, what a great site and informative posts, I will upload inbound link – bookmark this web site? Regards, Reader.
    回覆 # 1F
    於 2023-12-14 00:39:23 發表

    Hello! I could have sworn I’ve been to this blog before but after browsing through some of the post I realized it’s new to me.
    回覆 # 1F
    於 2023-12-14 00:39:08 發表

    Good info. Lucky me I reach on your website by accident, I bookmarked it.
    回覆 # 1F
    於 2023-12-14 00:35:10 發表

    After all, what a great site and informative posts, I will upload inbound link – bookmark this web site? Regards, Reader.
    回覆 # 1F
    於 2023-12-14 00:29:35 發表

    Good info. Lucky me I reach on your website by accident, I bookmarked it.
    回覆 # 1F
    於 2023-12-14 00:18:22 發表

    Nice article inspiring thanks. Hello Administ .
    回覆 # 1F
    於 2023-12-14 00:16:44 發表

    Thank you for great article. Hello Administ .
    回覆 # 1F
    於 2023-12-14 00:13:47 發表

    Thank you great posting about essential oil. Hello Administ .
    回覆 # 1F
    於 2023-12-14 00:12:47 發表

    Hi, just required you to know I he added your site to my Google bookmarks due to your layout. But seriously, I believe your internet site has 1 in the freshest theme I??ve came across.
    回覆 # 1F
    於 2023-12-14 00:12:05 發表

    Nice article inspiring thanks. Hello Administ .
    回覆 # 1F
    於 2023-12-13 20:49:32 發表

    Thank you great posting about essential oil. Hello Administ .
    回覆 # 1F
    於 2023-12-13 20:48:05 發表

    Thank you for great information. Hello Administ .
    回覆 # 1F
    於 2023-12-13 20:09:53 發表

    Hello! I could have sworn I’ve been to this blog before but after browsing through some of the post I realized it’s new to me.
    回覆 # 1F
    於 2023-12-13 19:01:25 發表

    Hi, just required you to know I he added your site to my Google bookmarks due to your layout. But seriously, I believe your internet site has 1 in the freshest theme I??ve came across.
    回覆 # 1F
    於 2023-12-13 12:07:24 發表

    Thank you for content. Area rugs and online home decor store. Hello Administ .
    回覆 # 1F
    於 2023-12-13 09:55:33 發表

    After all, what a great site and informative posts, I will upload inbound link – bookmark this web site? Regards, Reader.
    回覆 # 1F
    於 2023-12-13 08:25:49 發表

    Nice article inspiring thanks. Hello Administ .
    回覆 # 1F
    於 2023-12-13 08:25:32 發表

    Thank you for great content. Hello Administ.
    回覆 # 1F
    於 2023-12-12 23:26:53 發表

    After all, what a great site and informative posts, I will upload inbound link – bookmark this web site? Regards, Reader.
    回覆 # 1F
    於 2023-12-12 21:15:02 發表

    Hello! I could have sworn I’ve been to this blog before but after browsing through some of the post I realized it’s new to me.
    回覆 # 1F
    於 2023-12-12 16:41:31 發表

    Thank you for great article. Hello Administ .
    回覆 # 1F
    於 2023-12-12 16:41:15 發表

    Thank you for great content. Hello Administ.
    回覆 # 1F
    於 2023-12-12 11:05:01 發表

    I really love to read such an excellent article. Helpful article. Hello Administ .
    回覆 # 1F
    於 2023-12-12 11:04:40 發表

    Thank you for content. Area rugs and online home decor store. Hello Administ .
    回覆 # 1F
    於 2023-12-12 09:54:35 發表

    Thank you for great article. Hello Administ .
    回覆 # 1F
    於 2023-12-12 07:25:02 發表

    Everything is very open and very clear explanation of issues. was truly information.
    回覆 # 1F
    於 2023-12-10 21:39:15 發表

    Hi, just required you to know I he added your site to my Google bookmarks due to your layout. But seriously, I believe your internet site has 1 in the freshest theme I??ve came across.
    回覆 # 1F
    於 2023-12-10 21:28:58 發表

    After all, what a great site and informative posts, I will upload inbound link – bookmark this web site? Regards, Reader.
    回覆 # 1F
    於 2023-12-10 15:41:57 發表

    Nice article inspiring thanks. Hello Administ .
    回覆 # 1F
    於 2023-12-10 15:35:17 發表

    Everything is very open and very clear explanation of issues. was truly information.
    回覆 # 1F
    於 2022-12-08 15:52:35 發表

    But wanna say that this really is quite helpful Thanks for taking your time to write this.
    回覆 # 1F
    於 2022-12-07 11:52:06 發表

    Nice post. I learn something new and challenging on blogs I stumbleupon on a daily basis. https://izmirmerkitevdenevenakliyat.com/
    回覆 # 1F
    於 2022-12-02 20:30:36 發表

    I appreciate you sharing this blog.Really looking forward to read more. Really Great. https://freehorseracingtv.com/
    回覆 # 1F
    於 2022-11-29 18:15:17 發表

    I really love to read such an excellent article. Helpful article. Hello Administ . Casibom